The Protein Interactions Expert


Please browse below a selection of testimonials by our customers. Many more would be happy to share their views on our services.

Contact us and we will forward you the details of a colleague in your field, perhaps even in your institute or company!

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Plant Biology

I have been using the Y2H service from Hybrigenics for years and I’ve never been disappointed. Each of their screening provides us at least one solid protein-protein interaction which has been then confirmed by different in vitro and in planta approaches in my lab. My students can do Y2H in the lab as well, but it costs them a lot of time, especially when multiple proteins have to be screened. I have to say that the service from Hybrigenics is more professional and more reliable. And I also like their availability of a large amount of different libraries very much. It is very critical when I am not working on Arabidopsis, or having a membrane protein to deal with. We have good communication from the discussion of bait and library in the beginning, to the final completion, and I am always informed when there is any progress. I think I will keep working with Hybrigenics, and I definitely would like to recommend Hybrigenics to my colleagues.

Shan Lu, (Nanjing University, Nanjing, China) - RoW

My group has been using the services provided by Hybrigenics to perform y2H screens from Arabidopsis thaliana libraries using viral proteins as baits at several occasions, and has been very satisfied. Not only Hybrigenics teams have a great expertise in bait design, in performing high-coverage screens, and most importantly in scoring the candidates obtained and pinpointing the technical false-positives - which are invaluable assets, but I also found very enjoyable to work with them. They are friendly, supportive, and highly competent, and I always appreciated the discussions we had together. I will for sure never ever perform a yeast two-hybrid screen myself again and I strongly recommend their high-quality services, which are really worth the price. Moreover, following a very successful yeast two-hybrid screen using one of our viral protein as a bait, our group also got the chance to make use of their newly developed Hybribody service, i.e. synthetic single chains antibodies. Hybrigenics selected several VHH intrabodies, which they further validated in mammalian cells using fluorescence microscopy. Our lab is now currently validating them in plant cells and the preliminary data we obtained appear very promising. In addition to their use as basic research tools to detect our proteins in living cells, the intrabodies obtained may as well turn useful to inhibit key steps in the viral multiplication process, thus opening new possibilities for designing antiviral strategies.

Isabelle Jupin (Jacques Monod Institute, Paris, France) - Europe

We have worked together with Hybrigenics on the identification of protein-protein interactions through Y2H screens. They are really professional and you have a constant interaction with the staff in charge of your projects. It is reassuring to know that you deal with scientists who are able to discuss about specific issues regarding your projects, which makes them more similar to collaborators rather than mere service providers. They are also really thorough in their work, and are very experienced, which allows them to provide alternative solutions to all kinds of problems that may arise. In summary, I strongly recommend their services.

Alberto Macho (PSC, SIBS, CAS, Shanghai, China) - RoW

Hybrigenics, a company with full passion for science. I first learned about them at ASPB meeting and after that we started working on library prep. I must say, the scientific staff of Hybrigenics is a team of great guys. They worked as a colleague and helped us to design the screen. Their step-by-step updates starting from library prep to screen is incredibly great which keeps you updated all the time. Their program to support attending meeting is awesome. Being a personal beneficiary of this program, I would like to express my sincere gratitude. Looking forward to work more for our future projects, as per need. Great jobs guys… Kudos !!!

Prateek Tripathi (Molecular & Computational Biology University of Southern California, USA) - North America

I am very pleased with the yeast 2-hybrid services provided by Hybrigenics! The data are high quality and have helped to initiate new projects in my lab. Also, the staff are very knowledgeable and do a great job explaining the results of the screen. I will gladly use their services in the future!

Ram Dixit (Washington University, Saint-Louis, USA) - North America

My interactions with the Hybrigenics team have been excellent. From the beginning of our collaboration involving library preparation through the point of completing two Y2H screens, the Hybrigenics team communicated promptly, clearly, and effectively. They were also extremely flexible on addressing our specific needs, and we have been very happy with the outcomes of our projects.

Zach Lippman (CSHL, Cold Spring Harbor, USA) - North America

I have been very happy with the results. They have given us numerous leads for our research. I would definitely use Hybrigenics services again.

James Schoelz (University of Missouri, Columbia, USA) - North America

I requested Hybrigenics to perform a Y2H screen to test specific protein-protein interactions in the model plant Arabidopsis thaliana, the system I am working on. The results obtained by Hybrigenics were included in a nice paper recently published in Science (Velasquez et al. 2011). The results came back within two months with a very detailed bioinformatics analysis of the positive clones which helped me a lot to redefine my project. In addition, the experimental design of the bait together with the interpretation of the data was done together with the staff in Hybrigenics. I would strongly recommend doing Y2H with Hybrigenics.

Jose M. Estevez (University of Buenos Aires, Argentina) - RoW

We have used Hybrigenics services to screen a cDNA library of Arabidopsis for six different baits. We have obtained very good results for all of them. We have found the support service remarkably efficient and helpful providing scientific assistance and regular updates on the progress of the screens. We are very satisfied with this company and we will continue to use them in the future.

Federica Brandizzi (Michigan State University, USA) - North America
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