Protein Interaction Service and Tools- Hybrigenics Services

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Learn more about your small molecule with our target deconvolution service.

Our team working on Y2H experiments in the lab

Welcome to Hybrigenics Services, the protein interaction expert

Your number 1 partner for protein interaction studies.

Two lab technicians checking yeast growth for a yeast two hybrid screen

Upgrade to ULTImate Y2H^TM and associated protein interaction services.

Scientific assistance – Tailored approach – Exhaustive Yeast Two-Hybrid screening of highly complex libraries – Fully analyzed results.

Our scientists discussing the results of a protein interaction project

Accelerate your research & boost your drug target identification project

"Among all highly reliable interactions published by the scientific community, 3/4 are supported by at least one yeast two-hybrid experiment" Drs M. Vidal & S. Fields, Nature Methods, Dec. 2014 "

Our scientists presenting Hybrigenics' drug target identification services

Drug's target identification to increase your R&D project efficiency

Understand mechanism of action - anticipate potential side effects - support drug repositioning.

Publications

Hey1- and p53-dependent TrkC proapoptotic activity controls neuroblastoma growth

Ménard M, Costechareyre C, Ichim G, Blachier J, Neves D, Jarrosson-Wuilleme L, Depping R, Koster J, Saintigny P, Mehlen P, Tauszig-Delamasure S

Complement C3 Drives Autophagy-Dependent Restriction of Cyto-invasive Bacteria

Sorbara MT, Foerster EG, Tsalikis J, Abdel-Nour M, Mangiapane J, Sirluck-Schroeder I, Tattoli I, van Dalen R, Isenman DE, Rohde JR, Girardin SE, Philpott DJ

Disentangling the molecular determinants for Cenp-F localization to nuclear pores and kinetochores

Berto A, Yu J, Morchoisne-Bolhy S, Bertipaglia C, Vallee R, Dumont J, Ochsenbein F, Guerois R, Doye V

The striatal kinase DCLK3 produces neuroprotection against mutant huntingtin

Galvan L, Francelle L, Gaillard MC, de Longprez L, Carrillo-de Sauvage MA, Liot G, Cambon K, Stimmer L, Luccantoni S, Flament J, Valette J, de Chaldée M, Auregan G, Guillermier M, Joséphine C, Petit F, Jan C, Jarrige M, Dufour N, Bonvento G, Humbert S, Saudou F, Hantraye P, Merienne K, Bemelmans AP, Perrier AL, Déglon N, Brouillet E

Ehrlichia chaffeensis TRP75 Interacts with Host Cell Targets Involved in Homeostasis, Cytoskeleton Organization, and Apoptosis Regulation To Promote Infection

Luo T, Mitra S, McBride JW

Testimonials

I have been using the Y2H service from Hybrigenics for years and I’ve never been disappointed. Each of their screening provides us at least one solid protein-protein interaction which has been then...
Dr. Shan Lu, (Nanjing University, China)

My group has been using the services provided by Hybrigenics to perform y2H screens from Arabidopsis thaliana libraries using viral proteins as baits at several occasions, and has been very satisfi...
Dr. Isabelle Jupin (Jacques Monod Institute, Paris, France)

We have worked together with Hybrigenics on the identification of protein-protein interactions through Y2H screens. They are really professional and you have a constant interaction with the staff i...
PhD Alberto Macho (PSC, SIBS, CAS, Shanghai, China)

Hybrigenics conducted Y2H for our team. The huge Hybrigenics internal database provides additional confirmatory interaction information. I am very pleased to inform you that among the 18 hits obtai...
PhD Jiangping Wu (CHUM, Montreal, Quebec)

My laboratory carried out several two-hybrid screens, using a human placenta library. We designed the baits, and all of them but one gave great results, that were (and are being) validated as physi...
Pr. Sandra Citi (University of Geneva, Switzerland)

Hybrigenics, a company with full passion for science. I first learned about them at ASPB meeting and after that we started working on library prep. I must say, the scientific staff of Hybrigenics i...
Dr. Prateek Tripathi (Molecular & Computational Biology University of Southern California, USA)

The Hybrigenic screen that we commissioned produced excellent results, which strongly corroborated the results from another approach in the laboratory to identify host proteins that interact with r...
Dr. Charles Bangham (Imperial College London)

Our work with Hybrigenics aimed to deconvolute the potential target of a promising screening hit that we had previously identified in a phenotypic HTS campaign. Hybrigenics not only carried out the...
M. Matthias Baumann (Lead Discovery Center, Germany)

I have used the yeast-two-hybrid service provided by Hybrigenics, and was very satisfied. The staff members had expert knowledge and provided valuable updates and feedback. The provided informati...
Pr. Hans Netter (Monash University, Medicine, Nursing and Health Sciences, Australia)

My group has ordered two Y2H screens from Hybrigenics and we have been very happy with the excellent service they provide. Both screens have identified a significant number of novel interacting pro...
Dr. Andrew Peden ( University of Sheffield (CMIAD), United Kingdom)

We are interested in oligodendroglial cell maturation mainly in the context of myelin repair as it is highly relevant for the development of novel regenerative therapies for Multiple Sclerosis. Wit...
Dr. Patrick Küry (Heinrich-Heine University in Düsseldorf, Germany)

We employed the expertise of Hybrigenics following recommendation from a colleague. We were impressed by the efficiency and professionalism of this service, and the fact realistic timelines were gi...
Dr. Jenny Murdoch (Royal Holloway University of London, United Kingdom)

We have been thinking of performing a Y2H analysis for a while in order to get new insight on the interaction between coronavirus protein and cellular proteins in infected cells. A friend of mine t...
Dr. Marc Desforges (INRS-Institut Armand Frappier, Canada)

We have carried a Y2H screening with Hybrigenics on a totally unknown protein as a bait, and I was really impressed by the professionalism of their team and the quality of the work. Their custom...
Dr. Noureddine Ben Khalaf (Al-Jawhara Centre, Kingdom of Bahrain)

I am very pleased with the yeast 2-hybrid services provided by Hybrigenics! The data are high quality and have helped to initiate new projects in my lab. Also, the staff are very knowledgeable and...
Dr. Ram Dixit (Washington University in Saint-Louis, USA)

We successfully carried out a Y2H screen with Hybrigenics. We obtained excellent advice on designing our bait and choosing the best library for our studies. A large number of candidate interacting ...
Dr. Jean-Francois Cote (IRCM, Canada)

We have carried out one Y2H screen with Hybrigenics using a mouse adult brain cDNA library. The results of the screening were very satisfying and valuable to us. They included a very detailed analy...
Dr. Tomomi Aida (Tokyo Medical and Dental University, Japan)

My interactions with the Hybrigenics team have been excellent. From the beginning of our collaboration involving library preparation through the point of completing two Y2H screens, the Hybrigenics...
Dr. Zach Lippman (CSHL, USA)

Hybrigenics’ contribution to our HIV target identification and drug discovery programs was absolutely decisive. Thanks to their unparalleled Y2H technology, we discovered an interaction between a k...
Dr. Richard Benarous (Mutabilis, France)

I learnt about Hybrigenics from a colleague who recommended this company warmly. Having performed several two-hybrid screens myself, I was very impressed by the professionalism at Hybrigenics. The ...
Pr. Harald Stenmark (University of Oslo, Norway)

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