The Protein Interactions Expert

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Save time and money on your drug's discovery and development project

Learn more about your small molecule with our target deconvolution service.

Our team working on Y2H experiments in the lab

Welcome to Hybrigenics Services, the protein interaction expert

Your number 1 partner for protein interaction studies.

Two lab technicians checking yeast growth for a yeast two hybrid screen

Upgrade to ULTImate Y2HTM and associated protein interaction services.

Scientific assistance – Tailored approach – Exhaustive Yeast Two-Hybrid screening of highly complex libraries – Fully analyzed results.

Our scientists discussing the results of a protein interaction project

Accelerate your research & boost your drug target identification project

"Among all highly reliable interactions published by the scientific community, 3/4 are supported by at least one yeast two-hybrid experiment" Drs M. Vidal & S. Fields, Nature Methods, Dec. 2014 "

Our scientists presenting Hybrigenics' drug target identification services

Drug's target identification to increase your R&D project efficiency

Understand mechanism of action - anticipate potential side effects - support drug repositioning.

ENTREP/FAM189A2 encodes a new ITCH ubiquitin ligase activator that is downregulated in breast cancer

Tsunoda T, Riku M, Yamada N, Tsuchiya H, Tomita T, Suzuki M, Kizuki M, Inoko A, Ito H, Murotani K, Murakami H, Saeki Y, Kasai K

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An oomycete effector targets a plant RNA helicase involved in root development and defense

Camborde L, Kiselev A, Pel MJC, Le Ru A, Jauneau A, Pouzet C, Dumas B, Gaulin E

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I have been using the Y2H service from Hybrigenics for years and I’ve never been disappointed. Each of their screening provides us at least one solid protein-protein interaction which has been then...

Dr. Shan Lu, (Nanjing University, Nanjing, China)
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My group has been using the services provided by Hybrigenics to perform y2H screens from Arabidopsis thaliana libraries using viral proteins as baits at several occasions, and has been very satisfi...

Dr. Isabelle Jupin (Jacques Monod Institute, Paris, France)
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We have worked together with Hybrigenics on the identification of protein-protein interactions through Y2H screens. They are really professional and you have a constant interaction with the staff i...

PhD Alberto Macho (PSC, SIBS, CAS, Shanghai, China)
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Hybrigenics conducted Y2H for our team. The huge Hybrigenics internal database provides additional confirmatory interaction information. I am very pleased to inform you that among the 18 hits obtai...

PhD Jiangping Wu (CHUM, Montreal, Quebec)
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My laboratory carried out several two-hybrid screens, using a human placenta library. We designed the baits, and all of them but one gave great results, that were (and are being) validated as physi...

Pr. Sandra Citi (University of Geneva, Geneva, Switzerland)
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Hybrigenics, a company with full passion for science. I first learned about them at ASPB meeting and after that we started working on library prep. I must say, the scientific staff of Hybrigenics i...

Dr. Prateek Tripathi (Molecular & Computational Biology University of Southern California, USA)
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The Hybrigenic screen that we commissioned produced excellent results, which strongly corroborated the results from another approach in the laboratory to identify host proteins that interact with r...

Dr. Charles Bangham (Imperial College London, London, United Kingdom)
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Our work with Hybrigenics aimed to deconvolute the potential target of a promising screening hit that we had previously identified in a phenotypic HTS campaign. Hybrigenics not only carried out the...

M. Matthias Baumann (Lead Discovery Center, Dortmund, Germany)
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I have used the yeast-two-hybrid service provided by Hybrigenics, and was very satisfied. The staff members had expert knowledge and provided valuable updates and feedback. The provided informati...

Pr. Hans Netter (Monash University, Medicine, Nursing and Health Sciences, Australia)
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My group has ordered two Y2H screens from Hybrigenics and we have been very happy with the excellent service they provide. Both screens have identified a significant number of novel interacting pro...

Dr. Andrew Peden ( University of Sheffield (CMIAD), Sheffield, United Kingdom)
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We are interested in oligodendroglial cell maturation mainly in the context of myelin repair as it is highly relevant for the development of novel regenerative therapies for Multiple Sclerosis. Wit...

Dr. Patrick Küry (Heinrich-Heine University, Düsseldorf, Germany)
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We employed the expertise of Hybrigenics following recommendation from a colleague. We were impressed by the efficiency and professionalism of this service, and the fact realistic timelines were gi...

Dr. Jenny Murdoch (Royal Holloway University of London, London, United Kingdom)
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We have been thinking of performing a Y2H analysis for a while in order to get new insight on the interaction between coronavirus protein and cellular proteins in infected cells. A friend of mine t...

Dr. Marc Desforges (INRS-Institut Armand Frappier, Laval, Canada)
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We have carried a Y2H screening with Hybrigenics on a totally unknown protein as a bait, and I was really impressed by the professionalism of their team and the quality of the work. Their custom...

Dr. Noureddine Ben Khalaf (Al-Jawhara Centre, Kingdom of Bahrain)
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I am very pleased with the yeast 2-hybrid services provided by Hybrigenics! The data are high quality and have helped to initiate new projects in my lab. Also, the staff are very knowledgeable and...

Dr. Ram Dixit (Washington University, Saint-Louis, USA)
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We successfully carried out a Y2H screen with Hybrigenics. We obtained excellent advice on designing our bait and choosing the best library for our studies. A large number of candidate interacting ...

Dr. Jean-Francois Cote (IRCM, Montréal, Canada)
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We have carried out one Y2H screen with Hybrigenics using a mouse adult brain cDNA library. The results of the screening were very satisfying and valuable to us. They included a very detailed analy...

Dr. Tomomi Aida (Tokyo Medical and Dental University, Japan)
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My interactions with the Hybrigenics team have been excellent. From the beginning of our collaboration involving library preparation through the point of completing two Y2H screens, the Hybrigenics...

Dr. Zach Lippman (CSHL, Cold Spring Harbor, USA)
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Hybrigenics’ contribution to our HIV target identification and drug discovery programs was absolutely decisive. Thanks to their unparalleled Y2H technology, we discovered an interaction between a k...

Dr. Richard Benarous (Mutabilis, Paris, France)
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I learnt about Hybrigenics from a colleague who recommended this company warmly. Having performed several two-hybrid screens myself, I was very impressed by the professionalism at Hybrigenics. The ...

Pr. Harald Stenmark (University of Oslo, Norway)
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Your provider of protein interaction services

Whether you work in basic pharmaceutical, cosmetic or agro-biotech research, we provide you with cutting-edge services and protein interaction tools. Leader in the Yeast Two-Hybrid (Y2H) screening technology, we developed ULTImate Y2H™, the most exhaustive and reliable Yeast Two-Hybrid screening process.

Our company is also a key provider of drug profiling and target deconvolution services. To help you elucidate your small molecule ’s mechanism of action, we developed ULTImate YChemH, an extension of our screening process for drug target identification and compound profiling, using an optimized version of the Chemical Yeast Three-Hybrid (CY3H) technique.

Our optimized screening platform and our unique bioinformatics tools allow our scientists to provide you with a comprehensive offer and share with you Hybrigenics expertise to accelerate your research project. With more than 2500 academic & industrial researchers using our services from over 35 countries, Hybrigenics Services is internationally recognized and trusted as a protein interactions expert. Our results have been quoted in more than 500 scientific publications so far. You can check our customers' testimonials or watch our videos to learn how we run a protein interactions project.

Hybrigenics Services recently launched HYBRIBODY, a range of services for single-domain antibody selection and validation.
We select antibodies derived from a fully synthetic humanized VHH library and validate them for in vitro and in vivo applications (ELISA, IF, Intrabody…). More information on Hybribody is available on the dedicated website:

Contact our dedicated scientific team right now to start talking about your project.

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