The Protein Interactions Expert



Meet us at the Global Drug Discovery To Development Innovation Forum May 13-14 - London, UK Read more
Watch the video testimony of Dr Philippe Benaroch April - Paris, France Read more
Watch the video testimony of Dr Alexis Gautreau April - Paris, France Read more
Our team working on Y2H experiments in the lab

Welcome to Hybrigenics Services,

Your number 1 partner for protein interaction studies.

Two lab technicians checking yeast growth for a yeast two hybrid screen

Upgrade to ULTImate Y2HTM and associated services.

Scientific assistance – Tailored approach – Exhaustive screening of highly complex libraries – Fully analyzed results.

Our scientists discussing the results of a protein interaction project

Accelerate your research.

Fast and efficient service – Publication grade pictures – Detailed methods and experiment reports.

Our scientists presenting hybrigenics target identification services

Your science, your satisfaction.

Scientific assistance from project design to full review of the results with you.

Rio1 promotes rDNA stability and downregulates RNA polymerase I to ensure rDNA segregation

Iacovella MG, Golfieri C, Massari LF, Busnelli S, Pagliuca C, Dal Maschio M, Infantino V, Visintin R, Mechtler K, Ferreira-Cerca S, De Wulf P

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The Tumor Suppressor WWOX and HDAC3 Inhibit the Transcriptional Activity of the Beta-catenin Coactivator BCL9-2 in Breast Cancer Cells.

El-Hage P, Petitalot A, Monsoro-Burq AH, Maczkowiak F, Driouch K, Formstecher E, Camonis J, Sabbah M, Bieche I, Lidereau R, Lallemand F

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My group has ordered two Y2H screens from Hybrigenics and we have been very happy with the excellent service they provide. Both screens have identified a significant number of novel interacting pro...

Dr. Andrew Peden ( University of Sheffield (CMIAD), United Kingdom)
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We are interested in oligodendroglial cell maturation mainly in the context of myelin repair as it is highly relevant for the development of novel regenerative therapies for Multiple Sclerosis. Wit...

Dr. Patrick Küry (Heinrich-Heine University in Düsseldorf, Germany)
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We employed the expertise of Hybrigenics following recommendation from a colleague. We were impressed by the efficiency and professionalism of this service, and the fact realistic timelines were gi...

Dr. Jenny Murdoch (Royal Holloway University of London, United Kingdom)
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We have been thinking of performing a Y2H analysis for a while in order to get new insight on the interaction between coronavirus protein and cellular proteins in infected cells. A friend of mine t...

Dr. Marc Desforges (INRS-Institut Armand Frappier, Canada)
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We have carried a Y2H screening with Hybrigenics on a totally unknown protein as a bait, and I was really impressed by the professionalism of their team and the quality of the work. Their custom...

Dr. Noureddine Ben Khalaf (Al-Jawhara Centre, Kingdom of Bahrain)
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I am very pleased with the yeast 2-hybrid services provided by Hybrigenics! The data are high quality and have helped to initiate new projects in my lab. Also, the staff are very knowledgeable and...

Dr. Ram Dixit (Washington University in Saint-Louis, USA)
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We successfully carried out a Y2H screen with Hybrigenics. We obtained excellent advice on designing our bait and choosing the best library for our studies. A large number of candidate interacting ...

Dr. Jean-Francois Cote (IRCM, Canada)
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We have carried out one Y2H screen with Hybrigenics using a mouse adult brain cDNA library. The results of the screening were very satisfying and valuable to us. They included a very detailed analy...

Dr. Tomomi Aida (Tokyo Medical and Dental University, Japan)
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My interactions with the Hybrigenics team have been excellent. From the beginning of our collaboration involving library preparation through the point of completing two Y2H screens, the Hybrigenics...

Dr. Zach Lippman (CSHL, USA)
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Hybrigenics’ contribution to our HIV target identification and drug discovery programs was absolutely decisive. Thanks to their unparalleled Y2H technology, we discovered an interaction between a k...

Dr. Richard Benarous (Mutabilis, France)
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I learnt about Hybrigenics from a colleague who recommended this company warmly. Having performed several two-hybrid screens myself, I was very impressed by the professionalism at Hybrigenics. The ...

Pr. Harald Stenmark (University of Oslo, Norway)
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My laboratory carried out several screens with Hybrigenics in order to identify the partners of Rab GTPases, key regulators of intracellular traffic in eukaryotic cells. The results have been impre...

Dr. Bruno Goud (Institut Curie, France)
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I requested Hybrigenics to perform two yeast two hybrid screenings using both human and zebrafish gene. We could not set up to run in our lab due to cost, time and lack of zebrafish Y2H library. Th...

Dr. Tomoko Obara (University of Oklahoma Health Science Center, USA)
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We have enjoyed the interaction with the Hybrigenics team. They are professional, provided accurate and exciting results which lead our science to new frontiers. I recommended their services to ...

Dr. Orly Reiner (Weizmann Institute of Science, Israel)
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Working with Hybrigenics staff is more like having a collaborator than a service provider…staff is very knowledgeable and highly responsive..their expertise and novel methodology gives high hit rel...

Dr. Bhuminder Singh (Vanderbilt University, USA)
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Hybrigenics yeast two-hybrid screening is unparalleled in terms of completeness and quality of service. Moreover, their services are a tremendous value, as we could not set it up in our lab for ev...

Dr. Scott Hiebert (Vanderbilt University, USA)
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My laboratory carried out a Y2H screen using a brain fetal library to find proteins interacting with a cleaved domain of a transmembrane protein. Every part of the procedure was clearly explained ...

Dr. Bernard Rogister (University of Liège, Belgium)
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I have been very happy with the results. They have given us numerous leads for our research. I would definitely use Hybrigenics services again.

Dr. James Schoelz (University of Missouri, USA)
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My laboratory carried out a Y2H screen with Hybrigenics using a human fibroblast cDNA library. I was very pleased with the results that we got. When I first contacted Hybrigenics about carrying ou...

Dr. Grant Stewart (University of Birmingham, United Kingdom)
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I requested Hybrigenics to perform a Y2H screen to test specific protein-protein interactions in the model plant Arabidopsis thaliana, the system I am working on. The results obtained by Hybrigenic...

Dr. Jose M. Estevez (University of Buenos Aires, Argentina)
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Hybrigenics Services, your provider of protein interactions tools

Whether you work in basic, pharmaceutical, cosmetic or agro-biotech research, we provide you with cutting-edge services and protein interactions tools.

Leader in the yeast two-hybrid (Y2H) screening technology, we developed ULTImate Y2H™, the most exhaustive and reliable Y2H screening process.

The company is also a key provider of drug discovery services.

Among them, we developed ULTImate YChemH for small molecules, an extension of our screening process for target identification and compound profiling.

Our unique bioinformatics tools and our customer-dedicated organization allow our passionate scientists to share Hybrigenics Services expertise with 1,500+ customers around the world.



Contact us for your protein interaction project!