We are interested in oligodendroglial cell maturation mainly in the context of myelin repair as it is highly relevant for the development of novel regenerative therapies for Multiple Sclerosis. With our previous work we identified a novel inhibitory factor, encoded by the p57kip2 gene, regulating the efficiency of the glial differentiation process. In order to decipher the underlying mode of action of this regulator we searched for professional support in detecting protein binding partners. To this end we teamed up with Hybrigenics and performed an ULTIMATE Y2H screen. This turned out to be a very fruitful collaboration and provided us with new binding proteins and revealed the requested mode of action, which could finally be published (Göttle et al., Journal of Neuroscience 2015). Currently we are preparing another approach together with the company in order to reveal further protein/protein interactions in related contexts and we might even launch an INHIBIT project.
Patrick Küry (Heinrich-Heine University, Düsseldorf, Germany) -