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Paris - March 28
Dr Isabelle Richard and her team at Genethon (Evry, France) published the first protein interaction map centered on proteins involved in limb-girdle muscular dystrophies (LGMD): Blandin et al. Skeletal Muscle, 2013, 3(1):3, available here.
LGMD are a group of more than 20 different neuromuscular disorders that principally affect the proximal pelvic and shoulder girdle muscles. No curative treatment is currently available for LGMD, which pleads for the elucidation of the pathological mechanisms implicated in the diseases.
A total of 87 ULTImate Y2H™ screens were conducted by Hybrigenics Services on its human skeletal muscle library to derive the network of 1492 interactions connecting 1018 proteins. The entire dataset can be browsed freely using Hybrigenics’ dedicated PIMRider software; please see here the muscular interactome map.
Bioinformatics analysis and further experimental validation carried out in Isabelle Richard’s lab using co-immunoprecipation, proximity-ligation assay and co-localization establish this network as a highly valuable resource for future functional studies in the field.
Paris, France - March 27
A new higly complex cDNA library constructed from mouse ovaries is now available for screening with Hybrigenics ULTImate process.
The cDNA was synthesized from polyA+ RNA from 9 week old mouse ovaries of OF1 mouse strain.
Paris, France - March 19
On March 19, 2013, Hybrigenics Services participated to the kick-off meeting of the European FP7 research project, “AgedBrainSYSBIO”.
This project, of which Hybrigenics Services is a partner, is coordinated by Prof. Michel Simonneau, an expert in functional genomics applied to neurosciences at Sainte-Anne Hospital in Paris (INSERM U894 Psychiatry and Neurosciences)
Hybrigenics Services will perform ULTImate Y2HTM (yeast two-hybrid) screens on selected proteins strongly suspected to be involved in late-onset Alzheimer Disease (AD), to derive extensive protein interaction maps around them.
This information will be crossed with data from human genome-wide genetic association studies to get insight into the mechanisms of action of susceptibility genes for AD.
AgedBrainSYSBIO represents another contribution of Hybrigenics Services'expertise to large scale functional proteomics projects. Some of these protein interaction maps are already published and freely accessible on our PIMRider portal.
Coventry, UK - March 17-20
Meet us at the joint meeting of the British Societies for Cell and Developmental Biology that will be held in Warwick University, Coventry, UK, from March 17 to March 20.
Etienne Formstecher, Deputy General Manager, will attend this event and will be happy to meet you to discuss your projects. You can contact him here to arrange a meeting before the event.
Nashville, USA - March 05-08
Aurélie Scheer, marketing manager, and Valérie Hindié, scientific project leader will be in Nashville, TN, from March 5 to March 8.
They will attend the Vanderbilt Research Supplier Expo on March 6 (Light Hall Lobby, 11.00 am to 2.00 pm) and the workshop organized by Vanderbilt customers on "New protein interactions in cancer" (March 7, 3.00-5.00 pm, room 8989B Preston Research Building).
For a visit to your lab, please contact us here.